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Related Concept Videos

The Micturition Reflex01:26

The Micturition Reflex

Urination, or micturition involves the coordination of the bladder's detrusor muscle and two sphincters to ensure controlled bladder emptying.
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating urine...
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Indirect-acting cholinergic agonists, also known as anticholinesterases, exert their pharmacological effects by enhancing cholinergic transmission in various body parts, including the neuromuscular junction, autonomic cholinergic synapses, and the brain.
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A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
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Related Experiment Video

Updated: Jun 7, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
03:26

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Published on: August 28, 2020

Pharmacologic therapy for the neurogenic bladder.

Anne P Cameron1

  • 1Department of Urology, University of Michigan, 3875 Taubman Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109-5330, USA. annepell@med.umich.edu

The Urologic Clinics of North America
|October 20, 2010
PubMed
Summary

This review covers medical treatments for neurogenic bladder, focusing on spinal cord injury and multiple sclerosis. It discusses current medications and emerging therapies for better bladder management.

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Isolation and Culture of Primary Neurons and Glia from Adult Rat Urinary Bladder
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Last Updated: Jun 7, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
03:26

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Published on: August 28, 2020

Isolation and Culture of Primary Neurons and Glia from Adult Rat Urinary Bladder
06:18

Isolation and Culture of Primary Neurons and Glia from Adult Rat Urinary Bladder

Published on: May 23, 2020

Area of Science:

  • Urology
  • Neurology

Background:

  • Neurogenic bladder is a complex condition affecting individuals with neurological disorders.
  • Spinal cord injury (SCI) and multiple sclerosis (MS) are primary causes of neurogenic bladder.
  • Effective management is crucial for patient quality of life and preventing complications.

Purpose of the Study:

  • To review current and historical medical management strategies for neurogenic bladder.
  • To focus on treatments relevant to spinal cord injury and multiple sclerosis.
  • To explore novel therapeutic approaches in human and animal studies.

Main Methods:

  • Comprehensive literature review of existing studies.
  • Analysis of pharmacological interventions for neurogenic bladder.
  • Examination of emerging treatments in preclinical and clinical research.

Main Results:

  • Antimuscarinics, alpha-blockers, and tricyclic antidepressants are established treatments.
  • Combined use of these medications can enhance efficacy.
  • New therapies show promise in ongoing human and animal trials.

Conclusions:

  • Current medical management relies on established pharmacological agents.
  • Combination therapy offers a viable option for complex cases.
  • Future research and clinical trials are essential for advancing neurogenic bladder treatment.