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Updated: Jun 7, 2026
03:26
Detrusor Underactivity Model in Rats by Conus Medullaris Transection
Published on: August 28, 2020
Botulinum toxin therapy for neurogenic detrusor overactivity
Marc C Smaldone1, Benjamin T Ristau, Wendy W Leng
1Department of Urology, University of Pittsburgh School of Medicine, Suite 700, Kaufmann Building, 3471 5th Avenue, Pittsburgh, PA 15213, USA.
The Urologic Clinics of North America
|October 20, 2010
Summary
Botulinum toxin (BTX) injections offer a safe and effective treatment for neurogenic detrusor overactivity (NDO), improving bladder control and quality of life. Repeat treatments maintain efficacy over time.
Area of Science:
- Urology
- Neurology
- Pharmacology
Background:
- Neurogenic detrusor overactivity (NDO) presents a significant challenge in managing bladder dysfunction.
- Conservative therapies often prove insufficient for NDO patients.
- Botulinum toxin (BTX) injections are emerging as a promising therapeutic option.
Purpose of the Study:
- To review the current literature on the safety and efficacy of BTX injections for NDO.
- To summarize objective and subjective outcomes of BTX therapy in NDO patients.
Main Methods:
- Systematic review of existing studies on BTX bladder injections for NDO.
- Analysis of urodynamic parameters and patient-reported outcomes.
Main Results:
- BTX injections demonstrate significant improvements in continence and quality of life.
- Objective urodynamic findings include increased bladder capacity and compliance, and reduced voiding pressures.
- The therapy is generally well-tolerated with a low-risk profile.
Conclusions:
- BTX bladder injection is a safe and effective treatment for refractory NDO.
- Benefits include both subjective patient-reported improvements and objective urodynamic changes.
- Repeat injections are feasible and maintain therapeutic efficacy, though reinnervation limits duration.
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