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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

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Related Experiment Video

Updated: Jun 7, 2026

Methylated DNA Immunoprecipitation
21:24

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

Cancer epigenetics.

Rodolphe Taby1, Jean-Pierre J Issa

  • 1Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

CA: a Cancer Journal for Clinicians
|October 21, 2010
PubMed
Summary
This summary is machine-generated.

Epigenetics, stable gene expression changes without DNA alteration, is crucial in development and diseases like cancer. Targeting epigenetic modifiers offers therapeutic potential for cancers.

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An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
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Published on: April 5, 2018

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
07:50

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

Area of Science:

  • Molecular Biology
  • Genetics
  • Epigenetics

Background:

  • Epigenetics involves stable alterations in gene expression without changing the DNA sequence.
  • It plays a key role in normal physiological processes like differentiation, embryogenesis, and X chromosome inactivation.
  • Epigenetic mechanisms are increasingly recognized in complex diseases, including cancer.

Purpose of the Study:

  • To highlight the significance of epigenetic alterations in human carcinogenesis.
  • To discuss the role of epigenetic changes in regulating the neoplastic phenotype.
  • To underscore the therapeutic implications of targeting epigenetic modifiers in cancer treatment.

Main Methods:

  • Review of current scientific literature on epigenetics and cancer.
  • Analysis of molecular mechanisms including DNA methylation, histone modifications, and microRNA expression.
  • Examination of the impact of epigenetic changes on gene expression related to cancer.

Main Results:

  • Epigenetic changes, alongside genetic alterations, are essential for understanding human carcinogenesis.
  • These molecular changes lead to sustained alterations in genes controlling cellular growth and invasiveness.
  • Epigenetic therapy has shown success in treating hematopoietic malignancies.

Conclusions:

  • Epigenetic alterations are fundamental to cancer development and progression.
  • Targeting epigenetic modifiers is a validated therapeutic strategy for cancer.
  • Epigenetics holds promise for cancer prevention, diagnosis, risk stratification, and prognosis.