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Updated: Jun 7, 2026
Surgical Bone Implantation Technique for Rat Tibia Models of Diabetes and Osteoporosis
Published on: July 5, 2024
Homeopathic Symphytum officinale increases removal torque and radiographic bone density around titanium implants in
Rubens Spin-Neto1, Marina Montosa Belluci, Celso Eduardo Sakakura
1UNESP - Univ Estadual Paulista, Department of Periodontology, Araraquara, São Paulo, Brazil.
Introduction:
This study evaluated the effect of Symphytum officinale in homeopathic potency (6cH), on the removal torque and radiographic bone density around titanium implants, inserted in rats tibiae.
Methods:
Implants were placed in male rat tibiae, and the animals randomized to two groups (Control and S. officinale 6cH treated), which were evaluated at 7, 14, 28 and 56 days post-implantation. Radiographic bone density was measured at 6 points around the implant, using digital radiographic images, when implants were inserted and at sacrifice. Removal torque of the implants was also evaluated.
Results:
Both removal torque and radiographic bone density evaluation showed that S. officinale 6cH treatment enhanced bone formation around the micro-implants, mainly at 14 days. At 56 days, the radiographic bone density was higher in the treated group.
Conclusions:
We conclude that S. officinale 6cH enhances, principally at the early stages of osseointegration, bone formation around titanium implants in rats' tibiae, based on radiographic and mechanical analysis.
