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Translational proteomics: what can you do for true patients?
Cristobal Belda-Iniesta1, Javier de Castro, Rosario Perona
1Biomarkers and Experimental Therapeutics for Cancer Group, IdiPAZ, University Hospital La Paz, Madrid, Spain. cbelda.hulp@salud.madrid.org
Journal of Proteome Research
|October 28, 2010
Summary
Personalized medicine in oncology requires integrating targeted therapies with traditional treatments. Addressing unmet needs in clinical oncology will enhance patient care through advanced cancer proteomics.
Area of Science:
- Oncology
- Proteomics
- Translational Medicine
Background:
- Modern oncology increasingly relies on personalized medicine, targeting specific cancer cell proteins.
- Current clinical decisions heavily depend on histology and TNM staging, alongside traditional chemotherapy agents.
- A dual approach integrating novel targeted therapies with surgery, radiotherapy, and chemotherapy is emerging.
Purpose of the Study:
- To identify unmet needs for clinical oncologists in the era of personalized cancer care.
- To explore how cancer proteomics can provide greater value for individual patient treatment strategies.
- To bridge the gap between advanced molecular targeting and current clinical practice.
Main Methods:
- Review of current oncological treatment paradigms.
- Analysis of the role of biomarkers in therapeutic decision-making.
- Exploration of the potential of proteomics in clinical oncology.
Main Results:
- Histology and TNM staging remain primary biomarkers despite advances in targeted therapies.
- Classical chemotherapeutic drugs are still widely used alongside emerging treatments.
- A significant need exists to better integrate proteomic data into clinical oncology workflows.
Conclusions:
- Clinical oncology faces a duality of traditional and novel therapeutic approaches.
- Unmet needs in clinical oncology can be addressed by leveraging cancer proteomics.
- Enhanced integration of proteomic insights is crucial for advancing patient-centered cancer care.
Related Concept Videos
01:33Proteomics
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
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02:24Ribosome Profiling
Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique helps...
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01:31Translation
Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
01:31Translation
Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life