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[Y. pestis phage of a new serovar]

N N Novosel'tsev, V I Marchenkov

    Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
    |November 1, 1990
    PubMed

    Insights

    A novel Yersinia pestis phage, Phage II, was discovered in Central Asia. Its unique characteristics distinguish it as a new serovar 3 phage, differing from existing serovars 1 and 2.

    Area of Science:

    • Microbiology
    • Virology
    • Bacteriology

    Background:

    • Yersinia pestis (Y. pestis) is a significant bacterial pathogen.
    • Phage typing is crucial for Y. pestis surveillance and epidemiology.
    • Existing Y. pestis phages are classified into serovars, primarily 1 and 2.

    Purpose of the Study:

    • To characterize a newly isolated phage from Y. pestis strain 2247.
    • To determine the serological classification of the isolated phage.
    • To assess the phage's potential as a novel typing agent for Y. pestis.

    Main Methods:

    • Isolation of bacteriophage from Y. pestis strain 2247.
    • Characterization of phage morphology and biological properties.
    • Serological analysis to compare with known Y. pestis phages.

    Main Results:

    • Phage II was isolated from a Y. pestis strain from a Central Asian desert focus.
    • Phage II exhibits distinct properties compared to moderate phages of serovar 2.
    • No common serological features were found with known Y. pestis phages of serovars 1 and 2.

    Conclusions:

    • Phage II represents a new phage entity within the Y. pestis phage classification system.
    • The unique isolation source and specificity support its classification as a new serovar 3 Y. pestis phage.
    • This discovery expands the phage typing toolkit for Y. pestis, aiding in epidemiological studies.

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