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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...

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Updated: Jun 7, 2026

Pattern-based Search of Epigenomic Data Using GeNemo
06:38

Pattern-based Search of Epigenomic Data Using GeNemo

Published on: October 8, 2017

Computational Epigenetics: the new scientific paradigm.

Shen Jean Lim1, Tin Wee Tan, Joo Chuan Tong

  • 1Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117597

Bioinformation
|October 28, 2010
PubMed
Summary
This summary is machine-generated.

Computational tools are essential for epigenetics research, enabling analysis of complex genomic data to understand heritable traits without altering DNA sequence. This review covers key bioinformatics strategies and databases for epigenomic studies.

Keywords:
bioinformaticsepigenetic informaticsepigeneticsepigenomics

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Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
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Last Updated: Jun 7, 2026

Pattern-based Search of Epigenomic Data Using GeNemo
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An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
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10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

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Area of Science:

  • Computational Biology
  • Genomics
  • Epigenetics

Background:

  • Epigenetics studies non-gene factors influencing organism traits and functions.
  • Computational tools are crucial for analyzing complex genomic information in epigenetics.
  • Traditional methods alone are insufficient for these analyses.

Purpose of the Study:

  • To examine computational strategies for studying epigenetic factors.
  • To review important databases and bioinformatic tools in epigenomics.

Main Methods:

  • Review of existing computational strategies in epigenetics.
  • Identification and compilation of key databases and bioinformatic tools.

Main Results:

  • Computational tools are vital for directing experiments and generating hypotheses in epigenetics.
  • Epigenomics integrates multiple scientific disciplines for large-scale analysis.
  • A review of current computational approaches and resources is presented.

Conclusions:

  • Computational strategies are indispensable for advancing epigenetics research.
  • Epigenomics offers new avenues for understanding gene regulation, development, and disease.
  • The reviewed tools and databases support the growing field of epigenomic studies.