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Asthma I: Introduction

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

Asthma: Pathogenesis and Management

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

Asthma-IV: Diagnostic and Management

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:

Asthma III: Clinical Manifestations

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...

Asthma-I: Introduction

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

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Updated: Jun 7, 2026

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

Viral diversity in asthma.

Peter McErlean¹, Alyssa Greiman, Silvio Favoreto

¹Division of Allergy-Immunology, Feinberg School of Medicine, Northwestern University, 240 East Huron, McGaw M530h, Chicago, IL 60611, USA. p-mcerlean@northwestern.edu

Immunology and Allergy Clinics of North America

|October 30, 2010

Summary

This summary is machine-generated.

Respiratory viruses trigger asthma flare-ups, often needing urgent care. This review explores various viruses linked to asthma exacerbations, noting gaps in current knowledge.

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Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions

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Published on: September 22, 2023

Area of Science:

Pulmonology
Infectious Diseases
Virology

Background:

Asthma exacerbations are frequently triggered by viral infections.
Numerous respiratory viruses are implicated in both childhood and adult asthma.
Understanding the specific viral culprits is crucial for effective management.

Purpose of the Study:

To review the diverse range of respiratory viruses associated with asthma exacerbations.
To highlight current uncertainties in the understanding of virus-induced asthma.
To examine both common and newly identified viral pathogens.

Main Methods:

Literature review of studies on respiratory viruses and asthma.
Inclusion of both RNA and DNA viruses.
Focus on viral etiology of asthma exacerbations.

Main Results:

A wide array of respiratory viruses contribute to asthma exacerbations.
Significant diversity exists among implicated viral pathogens.
Several areas of uncertainty remain regarding virus-asthma interactions.

Conclusions:

Viral infections are a primary driver of asthma exacerbations.
Further research is needed to clarify the role of specific viruses.
Improved understanding may lead to better prevention and treatment strategies.