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Updated: Jun 7, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Published on: August 25, 2014
Neonatal cerebral abnormalities and later verbal and visuospatial working memory abilities of children born very
Caron A C Clark1, Lianne J Woodward
1Canterbury Child Development Research Group, Department of Psychology, University of Canterbury, Canterbury, New Zealand. cclark4@unl.edu
Insights
Very preterm children often show deficits in verbal and visuospatial working memory. Early brain abnormalities, particularly in visuospatial skills, are linked to these cognitive challenges in preterm infants.
Area of Science:
- Neuroscience
- Developmental Psychology
- Pediatrics
Background:
- Preterm birth is a significant risk factor for neurodevelopmental challenges.
- Working memory deficits can impact academic and daily functioning.
- Understanding the specific cognitive vulnerabilities in preterm children is crucial for early intervention.
Purpose of the Study:
- To investigate working memory performance in very preterm children compared to full-term controls.
- To explore the relationship between early cerebral abnormalities and working memory outcomes.
- To identify specific patterns of cognitive impairment associated with preterm birth.
Main Methods:
- Prospective, longitudinal study design.
- Structural magnetic resonance imaging (MRI) at term equivalent age.
- Assessment of verbal (Digit Span) and visuospatial (Corsi Blocks) working memory at 6 years corrected age.
Main Results:
- Very preterm children exhibited poorer verbal and visuospatial working memory than full-term controls.
- Preterm children without cerebral abnormalities performed similarly to full-term children.
- Verbal impairments were associated with moderate-severe cerebral abnormalities; visuospatial difficulties were linked to mild and moderate-severe abnormalities.
Conclusions:
- Very preterm children are vulnerable to visuospatial working memory impairments.
- Early neurological disturbances play a role in the development of these cognitive difficulties.
- Targeted interventions may be beneficial for preterm infants with identified neurological differences.
Abstract:
As part of a prospective, longitudinal study, 103 very preterm children underwent structural magnetic resonance (MR) imaging at term equivalent age and an assessment of verbal (Digit Span) and visuospatial (Corsi Blocks) working memory at 6 years corrected age. Compared to children born full term (N = 108), very preterm children were characterized by poorer verbal and visuospatial working memory performance. Very preterm children without cerebral abnormalities performed similarly to full-term children. Verbal impairments were largely confined to children with earlier moderate-severe cerebral abnormalities, while children with mild and moderate-severe abnormalities showed greater difficulties in visuospatial working memory. Findings suggest that very preterm children may be particularly vulnerable to visuospatial impairment. They also highlight the role of early neurological disturbance in the evolution of these difficulties.
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