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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform
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Published on: November 7, 2013

Cyclodextrin-based gene delivery systems.

Carmen Ortiz Mellet1, José M García Fernández, Juan M Benito

  • 1Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Apartado 553, E-41071 Sevilla, Spain. mellet@us.es

Chemical Society Reviews
|November 3, 2010
PubMed
Summary
This summary is machine-generated.

Cyclodextrins (CDs) can be chemically modified to enhance their interaction with genetic material. This review explores strategies for creating artificial viruses for advanced gene therapy applications.

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Area of Science:

  • Supramolecular chemistry
  • Nanotechnology
  • Biotechnology

Background:

  • Cyclodextrins (CDs) are known for forming inclusion complexes.
  • Chemical modification enhances CD applications in drug delivery, sensing, and enzyme mimicking.
  • CDs are still considered novel nanoobjects with untapped potential.

Purpose of the Study:

  • To review strategies for promoting interactions between CD conjugates and genetic material.
  • To exploit the anisotropy of the CD platform for enhanced applications.
  • To explore the development of artificial viruses for gene therapy.

Main Methods:

  • Covalent modification of CDs.
  • Self-assembling strategies for CD conjugates.
  • Supramolecular ligation techniques.

Main Results:

  • Various strategies effectively promote CD-genetic material interactions.
  • CD conjugates can be engineered to exploit their unique nanometric platform.
  • The review consolidates approaches for building artificial viruses.

Conclusions:

  • Chemical modification and supramolecular approaches offer powerful tools for CD-based gene therapy.
  • Exploiting CD anisotropy is key to developing efficient artificial viruses.
  • Further development holds promise for programmed and effective gene delivery.