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Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

2.7K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

17.0K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
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Autoimmune Disorders01:29

Autoimmune Disorders

1.9K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
1.9K
Inflammatory Response01:28

Inflammatory Response

17.1K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
17.1K
What is the Immune System?01:38

What is the Immune System?

133.3K
Overview
133.3K
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

3.5K
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
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Related Experiment Video

Updated: Feb 17, 2026

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
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Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Published on: November 8, 2016

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[Regulatory B cell and autoimmune disease].

Takashi Matsushita1

  • 1Department of Dermatology, Kanazawa University Graduate School of Medical Science, Japan.

Nihon Rinsho Men'Eki Gakkai Kaishi = Japanese Journal of Clinical Immunology
|November 5, 2010
PubMed
Summary

Regulatory B cells, which produce IL-10, are crucial immune regulators. These cells, including a unique CD1d(hi)CD5(+)CD19(hi) subset, effectively suppress inflammation and autoimmunity in mouse models.

Area of Science:

  • Immunology
  • Cell Biology

Context:

  • Regulatory B cells (Bregs) producing IL-10 are key immune components.
  • Diverse B cell subsets with regulatory functions identified in autoimmune diseases.
  • A unique CD1d(hi)CD5(+)CD19(hi) Breg subset discovered in mouse spleens.

Purpose:

  • To review current understanding of regulatory B cell function.
  • To contextualize findings within previous characterization studies of Bregs.

Summary:

  • Regulatory B cells are phenotypically diverse, with subsets like IL-10-producing B cells, CD5(+) B-1a cells, and CD1d(+) marginal zone B cells identified.
  • A novel, rare CD1d(hi)CD5(+)CD19(hi) Breg subset has been recently discovered.
  • These regulatory B cells demonstrate potent in vivo suppression of inflammation and autoimmunity in mouse models.

More Related Videos

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
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Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice

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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

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Related Experiment Videos

Last Updated: Feb 17, 2026

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
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Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Published on: November 8, 2016

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Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
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Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice

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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

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Impact:

  • Highlights the significant role of Bregs in immune regulation.
  • Provides a comprehensive overview of Breg identification and characterization.
  • Emphasizes the therapeutic potential of Bregs in managing autoimmune diseases.