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Updated: Jun 7, 2026

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
Published on: January 7, 2019
Sustained release of nucleic acids from polymeric nanoparticles using microemulsion precipitation in supercritical
Jun Ge1, Gunilla B Jacobson, Tatsiana Lobovkina
1Department of Chemistry, Stanford University, 333 Campus Drive, Stanford, CA 94305-5080, USA.
Abstract:
A general approach for producing biodegradable nanoparticles for sustained nucleic acid release is presented. The nanoparticles are produced by precipitating a water-in-oil microemulsion in supercritical CO(2). The microemulsion consists of a transfer RNA aqueous solution (water phase), dichloromethane containing poly(l-lactic acid)-poly(ethylene glycol) (oil phase), the surfactant n-octyl β-D-glucopyranoside, and the cosurfactant n-butanol.

