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Updated: Jun 7, 2026
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Multifocal Electroretinograms
Published on: December 4, 2011
Benign fleck retinal findings on multifocal ERG, microperimetry, and OCT
Alicia Galindo-Ferreiro1, M Rosa Sanabria, Eduardo Pérez-Salvador Garcia
1Complejo Asistencial de Palencia, Palencia, Spain.
Summary
Benign fleck retina, characterized by yellow-white RPE flecks, may involve subtle visual function deficits. Advanced testing revealed mild sensitivity decreases and subnormal electroretinogram responses in affected areas.
Area of Science:
- Ophthalmology
- Retinal Imaging
- Visual Electrophysiology
Background:
- Benign fleck retina is a condition characterized by asymptomatic yellow-white flecks in the retinal pigment epithelium (RPE).
- Previous understanding suggested this condition primarily involved RPE changes without significant functional impairment.
Observation:
- A middle-aged woman presented with symmetrical, widespread RPE flecks, sparing the macula.
- Standard visual function tests were normal, but advanced testing revealed abnormalities.
Findings:
- Multifocal electroretinogram (mfERG) showed slightly subnormal responses in specific retinal zones.
- Microperimetry confirmed reduced sensitivity in the same areas, correlating with hypoautofluorescent spots.
- Optical coherence tomography (OCT) revealed increased RPE thickness and autofluorescence within the flecks.
Implications:
- This study demonstrates that benign fleck retina can be associated with measurable functional deficits.
- mfERG and microperimetry are valuable tools for detecting subtle functional impairments in RPE disorders.
- These findings expand the understanding of benign fleck retina beyond purely structural changes.
