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Blepharoptosis After Intravitreal Anti-VEGF Injections: A Prospective Study.

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This summary is machine-generated.

Intravitreal injections of anti-VEGF drugs can cause eyelid drooping (ptosis) and alter eyelid contour. Speculum use during injections may contribute to this effect, impacting upper eyelid height.

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Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Oculoplastics

Background:

  • Intravitreal injections of anti-vascular endothelial growth factor (anti-VEGF) are a common treatment for retinal diseases.
  • Potential side effects on eyelid structures are not fully understood.
  • Objective evaluation of eyelid changes post-injection is needed.

Purpose of the Study:

  • To objectively assess changes in upper eyelid height and contour following intravitreal injections.
  • To determine the incidence of clinically significant ptosis after anti-VEGF treatment.
  • To investigate the potential role of speculum use in post-injection ptosis.

Main Methods:

  • Prospective, observational, multicentre study of patients receiving unilateral anti-VEGF intravitreal injections.
  • Comparison of injected eyes (cases) with non-injected contralateral eyes (controls).
  • Measurement of upper eyelid margin reflex distance (MRD1) and eyelid contour using ImageJ software at baseline, 6, and 12 months.
  • Definition of clinically significant ptosis as a decrease in MRD1 of ≥0.5 mm.

Main Results:

  • A statistically significant decrease in MRD1 and upper eyelid contour was observed in injected eyes at 6 and 12 months (p < 0.01).
  • Clinically significant ptosis occurred in 57.4% of patients at 12 months post-injection.
  • No significant changes were noted in the control eyes, suggesting the effect is related to the injection procedure.

Conclusions:

  • Repeated anti-VEGF intravitreal injections are associated with reduced upper eyelid height and altered contour.
  • The use of an eyelid speculum during intravitreal injections may be a contributing factor to post-injection ptosis.
  • Further investigation into preventative measures for ptosis following intravitreal injections is warranted.