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Veno-Venous Extracorporeal Membrane Oxygenation in a Mouse
Published on: October 24, 2018
Development of a collaborative program to provide extracorporeal membrane oxygenation for adults with refractory
David A Turner1, Walter L Williford, Michelle A Peters
1Division of Pediatric Critical Care Medicine, Department of Pediatrics, Duke Children's Hospital, Duke University Medical Center, Durham, NC, USA. David.Turner@Duke.edu
Insights
A rapid adult extracorporeal membrane oxygenation (ECMO) program was developed during the pH1N1 pandemic to treat severe hypoxemia. This demonstrates a healthcare system
Area of Science:
- Critical Care Medicine
- Pandemic Response
- Extracorporeal Membrane Oxygenation (ECMO)
Background:
- The pH1N1 influenza pandemic presented a critical need for advanced respiratory support in young adults with refractory hypoxemia.
- Existing neonatal and pediatric extracorporeal membrane oxygenation (ECMO) programs highlighted the potential for adult application.
Purpose of the Study:
- To describe the rapid development and implementation of a collaborative adult respiratory extracorporeal membrane oxygenation (ECMO) program.
- To address the urgent healthcare demands posed by the pH1N1 pandemic, specifically for young adults with severe respiratory failure.
Main Methods:
- A multidisciplinary and interdisciplinary approach was adopted to establish the adult ECMO program.
- Key implementation steps included securing administrative support, fostering collaborative leadership, and conducting extensive educational initiatives.
- Technical modifications were essential for adapting existing infrastructure to adult venovenous ECMO requirements.
Main Results:
- An adult venovenous extracorporeal membrane oxygenation program was successfully implemented within an 8-week timeframe.
- The program was developed in response to the successful use of ECMO in young adults with pH1N1-induced acute respiratory distress syndrome.
Conclusions:
- The rapid development and successful implementation of the adult ECMO program demonstrate a healthcare system's ability to respond effectively to urgent public health crises.
- This expansion successfully integrated all necessary components, complementing the established neonatal-pediatric ECMO services.
Objective:
We report the process used to rapidly develop a collaborative adult respiratory extracorporeal membrane oxygenation program as a response to caring for young adult patients with refractory hypoxemia in the setting of the pH1N1 pandemic.
Design:
Interdisciplinary response of a complex medical system to a public health crisis. PATIENTS, INTERVENTIONS, MEASUREMENTS, AND MAIN RESULTS: After the successful use of extracorporeal membrane oxygenation in young adults with pH1N1-induced acute respiratory distress syndrome refractory to conventional therapies, an adult venovenous extracorporeal membrane oxygenation program was implemented over an 8-wk period. Implementation of this program involved a number of key steps that were crucial in the development process, including administrative and institutional support, multidisciplinary leadership and collaboration, extensive interdisciplinary educational initiatives, and substantial technical modifications.
Conclusions:
In the setting of the pH1N1 influenza pandemic, an adult respiratory extracorporeal membrane oxygenation program was successfully developed to complement an established neonatal-pediatric program. This program expansion integrated all of the necessary components involved in the development process from start to finish and confirms that a healthcare system can respond very quickly and successfully to an urgent healthcare need.
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