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Updated: Jun 6, 2026
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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
Malaria induced acute renal failure: a single center experience
K V Kanodia1, P R Shah, A V Vanikar
1Department of Pathology, Laboratory Medicine, Transfusion Services and Immunohematology, Dr. H. L. Trivedi Institute of Transplantation Sciences (ITS) - Smt Gulabben Rasiklal Doshi and Smt Kamlaben Mafatlal Mehta Institute of Kidney Diseases & Research Centre (IKDRC), Civil Hospital Campus, Asarwa, Ahmadabad, Gujarat, India. ikdrcad1@sancharnet.in
Summary
Malaria can cause acute kidney injury, most often with Plasmodium falciparum. Early diagnosis and treatment, including dialysis, can improve outcomes and reduce mortality in patients with malarial acute renal failure.
Area of Science:
- Nephrology
- Infectious Diseases
- Tropical Medicine
Background:
- Malaria presents with diverse clinical symptoms, including severe renal complications like acute kidney injury (AKI).
- AKI in malaria can be life-threatening, necessitating a thorough understanding of its incidence, clinical course, and outcomes.
Purpose of the Study:
- To evaluate the incidence, clinical profile, outcomes, and mortality predictors in patients with malarial AKI.
- To identify risk factors associated with mortality in this patient population.
Main Methods:
- Retrospective analysis of medical records for malaria-induced AKI over two years.
- Inclusion criteria: peripheral smear-positive for malaria parasites and AKI.
Main Results:
- 100 cases (10.4%) of malaria-induced AKI identified among 958 AKI patients.
- Plasmodium falciparum was the predominant species (85%).
- High rates of oligo/anuria (82%) and need for hemodialysis (78%); mortality rate was 21%.
Conclusions:
- Malaria is a significant cause of AKI, particularly in Plasmodium falciparum infections.
- Predictors of mortality include low hemoglobin, oligo/anuria, hyperbilirubinemia, cerebral malaria, DIC, and high creatinine.
- Prompt diagnosis, dialysis, and supportive care are crucial for reducing mortality and improving renal recovery.
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