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Related Concept Videos

Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Protein-protein Interfaces02:04

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...
Protein-Protein Interfaces02:04

Protein-Protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...
Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...

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Related Experiment Video

Updated: Jun 6, 2026

Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay (PCA) in Living Cells
08:38

Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay (PCA) in Living Cells

Published on: March 3, 2015

The evolution of protein interaction networks.

Andreas Schüler1, Erich Bornberg-Bauer

  • 1Bioinformatics Division, School of Biological Sciences, Institute for Evolution and Biodiversity, University of Muenster, Münster, Germany.

Methods in Molecular Biology (Clifton, N.J.)
|November 11, 2010
PubMed
Summary

High-throughput methods enable mapping protein interaction networks. Despite similarities across species, gene evolution causes significant structural variations in these networks.

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Last Updated: Jun 6, 2026

Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay (PCA) in Living Cells
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Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation
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Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation

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Area of Science:

  • Systems Biology
  • Bioinformatics
  • Evolutionary Biology

Background:

  • High-throughput methods have enabled the creation of comprehensive protein interaction networks (PINs) in model organisms.
  • Research has focused on understanding the structural principles of PINs and their relation to biological functions.
  • PINs exhibit global structural similarities across distantly related species, but also show considerable variation.

Purpose of the Study:

  • To review the current understanding of protein interaction network structures.
  • To explore the evolutionary processes that have shaped these network structures.

Main Methods:

  • Comparative analysis of protein interaction networks across different species.
  • Review of existing literature on network structure and evolution.

Main Results:

  • Protein interaction networks display conserved structural features globally.
  • Gene duplication, loss, and point mutations contribute to network divergence.
  • Evolutionary dynamics play a crucial role in shaping the architecture of biological networks.

Conclusions:

  • Understanding the interplay between network structure and evolutionary processes is key to deciphering biological complexity.
  • Comparative network analysis provides insights into fundamental principles of molecular systems evolution.