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Related Experiment Video

Updated: May 1, 2026

Dissection of Xenopus laevis Neural Crest for in vitro Explant Culture or in vivo Transplantation
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Xenopus er71 is involved in vascular development.

Herbert Neuhaus1, Frank Müller, Thomas Hollemann

  • 1Martin-Luther-University Halle-Wittenberg, Institute for Physiological Chemistry, Halle, Germany. herbert.neuhaus@medizin.uni-halle.de

Developmental Dynamics : an Official Publication of the American Association of Anatomists
|November 12, 2010
PubMed
Summary

The study shows that ER71 is crucial for blood vessel formation (vasculogenesis) in Xenopus embryos. However, it does not impact the development of hematopoietic (blood) cells.

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Area of Science:

  • Developmental biology
  • Molecular genetics
  • Vertebrate embryogenesis

Background:

  • Vasculogenesis and hematopoiesis are interconnected processes in vertebrate development.
  • The hemangioblast is a recognized common progenitor for both vascular and hematopoietic cells.
  • Early vascular and hematopoietic cells in Xenopus originate from the anterior ventral blood island (aVBI).

Purpose of the Study:

  • To identify and characterize the Xenopus ortholog of the ER71 gene.
  • To investigate the role of ER71 in Xenopus embryonic development, specifically in vasculogenesis and hematopoiesis.

Main Methods:

  • Identification of the Xenopus ER71 ortholog.
  • Functional analysis of ER71 using knockdown or knockout techniques in Xenopus embryos.
  • Assessment of vascular and hematopoietic development in manipulated embryos.

Main Results:

  • The Xenopus ortholog of ER71 was identified.
  • ER71 function was found to be essential for proper vasculogenesis in Xenopus.
  • ER71 was determined to be non-essential for the development of hematopoietic cells in Xenopus.

Conclusions:

  • ER71 plays a critical role in embryonic blood vessel formation in Xenopus.
  • Unlike in other species, ER71 in Xenopus is not required for hematopoietic cell development.