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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

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Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
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Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

Targeted Therapy: Can It Substitute for Chemotherapy?

Florian Schütz1

  • 1Universitätsfrauenklinik Heidelberg, Germany.

Breast Care (Basel, Switzerland)
|November 16, 2010
PubMed
Summary

Targeted therapies, like trastuzumab for HER2-positive breast cancer, improve treatment by targeting specific cancer cells. New agents like tyrosine kinase inhibitors are also under investigation to reduce toxicity and enhance efficacy.

Area of Science:

  • Oncology
  • Pharmacology
  • Molecular Biology

Background:

  • The goal in oncology is to maximize treatment efficacy while minimizing toxicity.
  • Targeted therapies are crucial for identifying patient subgroups who benefit most from specific treatments.
  • Targeted therapies have become integral to managing both primary and metastatic breast cancer.

Purpose of the Study:

  • To review current targeted therapies used in clinical decisions for primary and metastatic breast cancer.
  • To highlight the role of specific agents like trastuzumab and bevacizumab.
  • To provide an overview of emerging targeted agents and strategies.

Main Methods:

  • Review of established and investigational targeted therapies in breast cancer treatment.
  • Focus on agents targeting specific molecular pathways, such as HER2/neu and vascular endothelial growth factor.

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  • Discussion of clinical relevance and future directions in targeted therapy research.

    • Main Results:

    • Trastuzumab, a humanized monoclonal antibody, is effective in HER2/neu-overexpressing breast tumors.
    • Bevacizumab targets vascular endothelial growth factor ligand A, inhibiting angiogenesis, with no known predictive factors.
    • Investigational agents include tyrosine kinase inhibitors and other small molecules.

    Conclusions:

    • Targeted therapies are essential for personalized breast cancer treatment, improving outcomes by targeting specific tumor characteristics.
    • Trastuzumab demonstrates significant efficacy in HER2-positive breast cancer.
    • Ongoing research into novel targeted agents and strategies promises further advancements in reducing treatment toxicity and improving patient care.