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Updated: Jun 6, 2026

Tracking Mouse Bone Marrow Monocytes In Vivo
Published on: February 27, 2015
CXCL12 and CXCR4 in bone marrow physiology
Natalia M Moll1, Richard M Ransohoff
1CRICM / INSERM-UPMC, UMRS 975/CNRS UMR 7225, Faculté de Médecine Pierre et Marie Curie, Hôpital Pitié-Salpêtrière, 105 bd. de l'Hôpital, 75634 Paris, France. natalia.moll@upmc.fr
The CXCL12/CXCR4 axis regulates hematopoietic stem cell (HSC) development, migration, and survival in bone marrow niches. This review covers HSC homing, mobilization, and the emerging role of the CXCR7 receptor.
Area of Science:
- Hematology
- Cell Biology
- Immunology
Background:
- Hematopoietic stem cells (HSCs) reside in specific bone marrow (BM) niches.
- The CXCL12/CXCR4 axis plays a critical role in HSC regulation.
Purpose of the Study:
- To review the multifaceted roles of CXCL12 and CXCR4 in HSC development and function.
- To summarize signaling pathways mediating CXCL12/CXCR4 effects.
- To discuss HSC homing, mobilization, and the novel receptor CXCR7.
Main Methods:
- Literature review of studies on CXCL12, CXCR4, and HSCs.
- Analysis of signaling pathways involved in HSC regulation.
- Examination of mechanisms for HSC homing and mobilization.
Main Results:
- CXCL12/CXCR4 interaction influences HSC migration, proliferation, survival, and apoptosis.
- The CXCL12/CXCR4 pair is essential for HSC homing and repopulation within BM niches.
- Mechanisms of HSC mobilization and the role of CXCR7 are discussed.
Conclusions:
- The CXCL12/CXCR4 axis is a key regulator of HSC behavior in the bone marrow.
- Understanding these interactions is crucial for HSC research and therapeutic strategies.
- CXCR7 represents a new dimension in CXCL12-mediated HSC regulation.
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