CXCL12 and CXCR4 in bone marrow physiology

Natalia M Moll1, Richard M Ransohoff

  • 1CRICM / INSERM-UPMC, UMRS 975/CNRS UMR 7225, Faculté de Médecine Pierre et Marie Curie, Hôpital Pitié-Salpêtrière, 105 bd. de l'Hôpital, 75634 Paris, France. natalia.moll@upmc.fr

Expert Review of Hematology
|November 19, 2010
PubMed
Summary

The CXCL12/CXCR4 axis regulates hematopoietic stem cell (HSC) development, migration, and survival in bone marrow niches. This review covers HSC homing, mobilization, and the emerging role of the CXCR7 receptor.

Related Concept Videos

Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
Hematopoiesis01:21

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...