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Lycoperdonosis in two dogs.

Theresa Alenghat1, Cara A Pillitteri, David A Bemis

  • 1University of Pennsylvania School of Veterinary Medicine, Room 4005 MJR-VHUP, 3850 Spruce Street, Philadelphia, PA 19104, USA. alenghat@vet.upenn.edu

Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
|November 20, 2010
PubMed
Summary
This summary is machine-generated.

Canine lycoperdonosis, a rare respiratory disease caused by puffball mushroom spores, was diagnosed in two dogs. Early airway sampling may aid in detecting these fungal spores.

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Area of Science:

  • Veterinary Pathology
  • Mycology
  • Respiratory Medicine

Background:

  • Lycoperdonosis is an uncommon respiratory condition triggered by inhaling spores from Lycoperdon (puffball) mushrooms.
  • This study details two confirmed cases of canine lycoperdonosis, highlighting the disease's impact on dogs.

Observation:

  • Both affected dogs exhibited respiratory distress after exposure to puffball mushroom-rich environments.
  • Radiographic findings included diffuse interstitial and multifocal alveolar patterns in the lungs.
  • Histopathology revealed severe pyogranulomatous pneumonia and the presence of Lycoperdon spores within macrophages.

Findings:

  • Polymerase chain reaction analysis confirmed the presence of Lycoperdon pyriforme DNA in lung tissue.
  • Microscopic examination identified characteristic fungal spores (3-5 µm) in lung and lymph node tissues.
  • Re-examination of an endotracheal wash sample showed intrahistiocytic spores, indicating potential diagnostic value.

Implications:

  • This research contributes to understanding canine lycoperdonosis, a rare but severe fungal respiratory disease.
  • The findings suggest that endotracheal washes may be a valuable diagnostic tool for early detection.
  • Further research into Lycoperdonosis pathogenesis and treatment in canines is warranted.