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Updated: Jun 6, 2026

Dynamic Assessments of Coronary Flow Reserve after Myocardial Ischemia Reperfusion in Mice

Dynamic Assessments of Coronary Flow Reserve after Myocardial Ischemia Reperfusion in Mice

Published on: August 25, 2023

Intestinal ischemia/reperfusion: microcirculatory pathology and functional consequences.

Brigitte Vollmar¹, Michael D Menger

¹Institute for Experimental Surgery, University of Rostock, Schillingallee 69a, 18055, Rostock, Germany. brigitte.vollmar@med.uni-rostock.de

Langenbeck'S Archives of Surgery

|November 20, 2010

Summary

Intestinal ischemia and reperfusion (I/R) injury involves microcirculatory failure, leading to inflammation and barrier dysfunction. Understanding these mechanisms offers new diagnostic and therapeutic strategies for better patient outcomes.

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Murine Model of Intestinal Ischemia-reperfusion Injury

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Murine Model of Intestinal Ischemia-reperfusion Injury

Murine Model of Intestinal Ischemia-reperfusion Injury

Published on: May 11, 2016

Area of Science:

Gastroenterology
Surgical Research
Pathophysiology

Background:

Intestinal ischemia and reperfusion (I/R) presents a significant clinical challenge with high mortality rates.
Delayed diagnosis and treatment exacerbate the severity of I/R injury.

Purpose of the Study:

To review the fundamental mechanisms underlying intestinal microcirculatory dysfunction in I/R injury.
To identify potential therapeutic targets for mitigating I/R-induced damage.

Main Methods:

Comprehensive review of experimental research on intestinal I/R injury.
Analysis of microcirculatory dysfunctions and inflammatory responses.
Examination of epithelial barrier integrity and bacterial translocation.

Main Results:

Microcirculatory dysfunctions are key drivers of intestinal I/R injury.
Failure of nutritive perfusion, inflammatory cell infiltration, and mediator surges characterize I/R.
Epithelial barrier breakdown and bacterial translocation contribute to systemic inflammation.

Conclusions:

Translational research is needed to apply experimental findings to clinical settings.
Understanding I/R pathophysiology can lead to novel diagnostic and therapeutic interventions.
Improved patient outcomes are anticipated with enhanced I/R management strategies.