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Related Experiment Video

Updated: Jun 6, 2026

Characterization of the Isolated, Ventilated, and Instrumented Mouse Lung Perfused with Pulsatile Flow

Characterization of the Isolated, Ventilated, and Instrumented Mouse Lung Perfused with Pulsatile Flow

Published on: April 29, 2011

Description of a flow optimized oxygenator with integrated pulsatile pump.

Ralf Borchardt¹, Peter Schlanstein, Jutta Arens

¹Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, Aachen, Germany. borchardt@hia.rwth-aachen.de

Artificial Organs

|November 25, 2010

Summary

A novel pulsatile blood pump integrated into an oxygenator shows promise for infant extracorporeal membrane oxygenation (ECMO). This new design offers a viable alternative for pediatric ECMO systems.

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Last Updated: Jun 6, 2026

Characterization of the Isolated, Ventilated, and Instrumented Mouse Lung Perfused with Pulsatile Flow

Characterization of the Isolated, Ventilated, and Instrumented Mouse Lung Perfused with Pulsatile Flow

Published on: April 29, 2011

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Maintaining and Assessing Various Tissue and Cell Types of the Eye Using a Novel Pumpless Fluidics System

Published on: July 14, 2023

Area of Science:

Biomedical Engineering
Cardiopulmonary Support
Pediatric Medical Devices

Background:

Extracorporeal membrane oxygenation (ECMO) is crucial for neonatal and pediatric patients with severe lung and heart conditions.
Existing ECMO systems utilize separate non-pulsatile blood pumps and oxygenators.
There is a need for integrated, potentially pulsatile pump solutions for small infant ECMO.

Purpose of the Study:

To develop and evaluate a novel oxygenator with an integrated pulsatile blood pump for infant ECMO.
To assess the functionality and gas exchange capabilities of this new integrated system.
To identify areas for design optimization to enhance performance.

Main Methods:

Development of a pulsatile pump module using air-driven silicone tubes (STs) integrated within an oxygenator's fiber bundle.
Testing of the integrated system for blood pumping functionality and gas exchange rates.
Analysis of factors affecting gas exchange efficiency, including fiber packing density and blood flow distribution.

Main Results:

The integrated pulsatile silicone tube (ST) pump module demonstrated viable blood pumping functionality.
A maximum oxygen gas exchange rate of 48 mL/min/L(blood) was achieved at a blood flow rate of approximately 300 mL/min.
Manual manufacturing resulted in lower hollow-fiber packing density compared to commercial oxygenators.

Conclusions:

Pulsatile blood pumping using integrated STs is a feasible concept for future ECMO devices.
Optimization of fiber packing density and blood flow distribution is critical for improving gas exchange rates.
Further design refinements, including uniform fiber placement and distribution plates, are recommended for enhanced performance.