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A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
Published on: August 8, 2014
Periodontal disease is related to local and systemic mediators of inflammation
1Graduate Program in Clinical Research, New York University College of Dentistry, 250 Park Ave South, 6th Floor - Room 646, New York, NY 10003-1402, USA. ad75@nyu.edu
Article Title And Bibliographic Information:
Local and systemic biomarkers in gingival crevicular fluid increase odds of periodontitis. Fitzsimmons TR, Sanders AE, Bartold PM, Slade GD. J Clin Periodontol 2010;37(1):30-6.
Reviewer:
Ananda P. Dasanayake, BDS, MPH, PhD, FACE.
Purpose/Question:
The authors attempted to study the independent and combined effects of local (IL-1β) and systemic (CRP) inflammatory biomarkers in gingival crevicular fluid (GCF) on the risk of periodontitis.
Source Of Funding:
Government: National Health and Medical Research Council (NHMRC) of Australia and NHMRC Sidney Sax Public Health Fellowship.
Type Of Study/Design:
Case-control study.
Level Of Evidence:
Level 2: Limited-quality, patient-oriented evidence.
Strength Of Recommendation Grade:
Not applicable.
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