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The disposition of tert-butyl-D-serine in the rat
S Knott1, A Warrander, P J Phillips
1Drug Metabolism Section, ICI Pharmaceuticals, Macclesfield, UK.
Xenobiotica; the Fate of Foreign Compounds in Biological Systems
|January 1, 1990
Abstract:
1. Following intravenous administration of 14C-tert-butyl-D-serine to rats, radioactivity was eliminated rapidly via the kidneys. 2. One metabolite was detected in urine and was identified as the N-acetyl derivative of tert-butyl-serine. 3. Elimination was more rapid in female than male rats.