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Biobehavioral influences on cancer progression
Erin S Costanzo1, Anil K Sood, Susan K Lutgendorf
1Department of Psychiatry, Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, 6001 Research Park Boulevard, Madison, WI 53719, USA. ecostanzo@wisc.edu
Immunology and Allergy Clinics of North America
|November 25, 2010
Summary
This review explores how stress-related behaviors influence cancer growth and spread. It details the biobehavioral mechanisms and interventions for cancer patients.
Area of Science:
- Oncology
- Behavioral Science
- Psychoneuroimmunology
Background:
- Stress significantly impacts physiological pathways relevant to cancer.
- Behavioral factors modulate the stress response, influencing cancer progression.
- Neuroendocrine regulation plays a key role in these biobehavioral pathways.
Purpose of the Study:
- To review the contribution of stress-related behavioral factors to cancer growth and metastasis.
- To elucidate the biobehavioral mechanisms linking stress and cancer.
- To discuss potential interventions for cancer patients.
Main Methods:
- Literature review of studies on stress, behavior, and cancer.
- Analysis of neuroendocrine and physiological pathways involved.
- Examination of consequences for cancer progression and quality of life.
Main Results:
- Stress-related behaviors can promote tumor growth, angiogenesis, invasion, and metastasis.
- Alterations in immune response and inflammation are key mechanisms.
- These factors negatively impact patient quality of life.
Conclusions:
- Understanding biobehavioral mechanisms is crucial for cancer management.
- Behavioral and pharmacologic interventions show promise in altering cancer progression.
- Targeting stress-related pathways can improve outcomes for cancer patients.
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