Related Experiment Video
Updated: Jun 6, 2026

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
Published on: September 15, 2017
Clec14a is specifically expressed in endothelial cells and mediates cell to cell adhesion
Seung-Sik Rho1, Hyun-Jung Choi, Jeong-Ki Min
1Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea.
Abstract:
Clec14a is a member of the thrombomodulin (TM) family, but its function has not yet been determined. Here, we report that Clec14a is a plasma membrane protein of endothelial cells (ECs) expressed specifically in the vasculature of mice. Deletion mutant analysis revealed that Clec14a mediates cell-cell adhesion through its C-type lectin-like domain. Knockdown of Clec14a in ECs suppressed cell migratory activity and filopodial protrusion, and delayed formation of tube-like structures. These findings demonstrate that Clec14a is a novel EC-specific protein that appears to play a role in cell-cell adhesion and angiogenesis.
Related Concept Videos
Selectins
Cadherins in Tissue Organization
Cell Sorting During Development
Cell sorting plays an...
Adherens Junctions
Adherens Junctions are Dynamic
The endothelial cells...
Anchoring Junctions
Regulation of Angiogenesis and Blood Supply
Structure of Cadherins

