Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 6, 2026

Ultrahigh Resolution Mouse Optical Coherence Tomography to Aid Intraocular Injection in Retinal Gene Therapy Research
10:10

Ultrahigh Resolution Mouse Optical Coherence Tomography to Aid Intraocular Injection in Retinal Gene Therapy Research

Published on: November 2, 2018

Retinal vessel cannulation with an image-guided handheld robot.

Brian C Becker1, Sandrine Voros, Louis A Lobes

  • 1Robotics Institute, Carnegie Mellon University, Pittsburgh, PA 15213, USA.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
|November 25, 2010
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Examining the effects of cigarette smoke on mouse lens through a multi OMIC approach.

Scientific reports·2026
Same author

Diabetes Equipment Accessibility Standards 2 Decades Late.

JAMA ophthalmology·2026
Same author

Toward autonomous robotic-assisted and microrobotic surgery.

Science advances·2026
Same author

A critical role for mitochondrial dynamics in cigarette smoke condensate-induced RPE senescence.

Free radical biology & medicine·2026
Same author

Case Report: Bilateral optic nerve head masses and retinopathy in a patient with B-cell acute lymphoblastic leukemia receiving CAR T-cell therapy masquerading as fungal endophthalmitis.

Frontiers in immunology·2026
Same author

Isolation and Characterization of Extracellular Vesicles from Mouse Retina Tissue.

bioRxiv : the preprint server for biology·2026

Surgeons can now cannulate tiny retinal vessels with greater success using a novel robotic micromanipulator. This image-guided system reduces tremor, improving surgical outcomes for delicate eye procedures.

Area of Science:

  • Ophthalmology
  • Robotic Surgery
  • Biomedical Engineering

Background:

  • Cannulating small retinal vessels (40-120 micrometers) is challenging due to physiological tremor.
  • Current surgical techniques have limited success rates for these delicate procedures.

Purpose of the Study:

  • To introduce an image-guided robotic system with an active handheld micromanipulator.
  • To assess the system's ability to reduce tremor and enhance motion control during retinal vessel cannulation.

Main Methods:

  • Development of an active handheld micromanipulator integrated into an image-guided robotic system.
  • The system tracks the pipette and ocular anatomy under microscopic visualization.
  • Ex vivo experiments on porcine eyes with 40-60 micrometer retinal vessels performed by an experienced retinal surgeon.

More Related Videos

Isolation of Retinal Arterioles for Ex Vivo Cell Physiology Studies
12:42

Isolation of Retinal Arterioles for Ex Vivo Cell Physiology Studies

Published on: July 14, 2018

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases
11:20

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases

Published on: June 14, 2021

Related Experiment Videos

Last Updated: Jun 6, 2026

Ultrahigh Resolution Mouse Optical Coherence Tomography to Aid Intraocular Injection in Retinal Gene Therapy Research
10:10

Ultrahigh Resolution Mouse Optical Coherence Tomography to Aid Intraocular Injection in Retinal Gene Therapy Research

Published on: November 2, 2018

Isolation of Retinal Arterioles for Ex Vivo Cell Physiology Studies
12:42

Isolation of Retinal Arterioles for Ex Vivo Cell Physiology Studies

Published on: July 14, 2018

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases
11:20

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases

Published on: June 14, 2021

Main Results:

  • The robotic system significantly improved the success rate of retinal vessel cannulation.
  • Success rate increased from 29% (2/7) without the system to 63% (5/8) with the system.
  • The micromanipulator provided smooth, scaled motion, aiding approach, puncture, and injection stages.

Conclusions:

  • The image-guided robotic micromanipulator is a promising tool for improving surgical precision in retinal vessel cannulation.
  • This technology has the potential to overcome the limitations imposed by physiological tremor in microsurgery.
  • Further development could enhance outcomes for various delicate ophthalmic procedures.