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A Computational Modeling Approach to Investigate the Influence of Hyperthermia on the Tumor Microenvironment
Published on: December 1, 2023
Analytical validation of COMSOL Multiphysics for theoretical models of Radiofrequency ablation including the
Maria J Rivera1, Juan A López Molina, Macarena Trujillo
1Departamento de Matemática Aplicada, Instituto de Matemática Pura y Aplicada, Universidad Politécnica de Valencia, Spain. mjrivera@mat.upv.es
Abstract:
In this paper we outline our main findings about the differences between the use of the Bioheat Equation and the Hyperbolic Bioheat Equation in theoretical models for Radiofrequency (RF) ablation. At the moment, we have been working on the analytical approach to solve both equations, but more recently, we have considered numerical models based on the Finite Element Method (FEM). As a first step to use FEM, we conducted a comparative study between the temperature profiles obtained from the analytical solutions and those obtained from FEM. Regarding the differences between both methods, we obtain agreement in less than 5% of relative differences. Then FEM is a good alternative to model heating of biological tissues using BE and HBE in, for example, more complex and realistic geometries.
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