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Related Concept Videos

Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
Atypical Pneumonia01:14

Atypical Pneumonia

Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...
Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
Myasthenia Gravis ll: Pathophysiology01:22

Myasthenia Gravis ll: Pathophysiology

The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...
Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
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Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy
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Pyomyositis.

Haris Marath1, Max Yates, Martin Lee

  • 1Elsie Bertram Diabetes Centre, Norfolk and Norwich University Hospital Foundation Trust, Colney Lane, NR4 7UY, Norwich, Norfolk, UK.

Journal of Diabetes and Its Complications
|November 26, 2010
PubMed
Summary
This summary is machine-generated.

Poorly controlled diabetes increases infection risk. Unrecognized pyomyositis, a severe diabetic complication, highlights the need for specialist assessment of prolonged, unexplained symptoms in primary care.

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Last Updated: Jun 6, 2026

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy
10:55

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy

Published on: October 31, 2025

Area of Science:

  • Infectious diseases
  • Endocrinology
  • Primary care medicine

Background:

  • Diabetes mellitus is a growing global health concern.
  • Poor glycemic control significantly elevates the risk of infectious complications.
  • Primary care settings manage a large and increasing number of patients with diabetes.

Observation:

  • A case of pyomyositis, a deep muscle infection, occurred in a patient with poorly controlled diabetes.
  • This severe complication was initially unrecognized within the community setting.
  • The patient presented with prolonged, unexplained symptoms.

Findings:

  • Pyomyositis is an uncommon but serious infectious complication associated with poorly controlled diabetes.
  • Delayed diagnosis can lead to significant morbidity.
  • Primary care physicians require heightened awareness of this condition.

Implications:

  • Clinicians managing diabetic patients must consider pyomyositis in cases of prolonged, unexplained symptoms.
  • Prompt specialist assessment is crucial for timely diagnosis and management of diabetic infectious complications.
  • Enhanced diagnostic awareness in primary care can improve patient outcomes for individuals with diabetes.