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Updated: Jun 6, 2026

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A High-Throughput In Situ Method for Estimation of Hepatocyte Nuclear Ploidy in Mice
Published on: April 19, 2020
Nuclear ploidy is an indicator of malignancy endocrine pancreatic tumor
E A Dubova1, M N Podgornova, A I Shchyogolev
1Department of Pathological Anatomy, A. V. Vishnevsky Institute of Surgery, Moscow, Russia.
Bulletin of Experimental Biology and Medicine
|November 30, 2010
Abstract:
Comparative morphometric and densitometric studies of cell nuclei in endocrine tumors of various differentiation degree and endocrinocytes of Langerhans islet in the adjacent pancreatic tissue were carried out. Index of proliferative activity, aneuploidy coefficient, and histogram of nuclear DNA content are recommended as additional criteria for the diagnosis of endocrine tumor malignancy.
