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Updated: Jun 6, 2026
05:44
Ultrasonographic Evaluation of Breast Cancer-related Lymphedema
Published on: January 12, 2017
Physical activity and breast cancer prevention
Brigid M Lynch1, Heather K Neilson, Christine M Friedenreich
1Department of Population Health Research, Alberta Health Services-Cancer Care, 1331 29 St NW, Calgary, Alberta, Canada, T2N 4N2.
Summary
Regular physical activity significantly reduces breast cancer risk by an average of 25%. This protective effect is most pronounced with moderate-to-vigorous intensity exercise, especially after menopause.
Area of Science:
- Epidemiology
- Oncology
- Preventive Medicine
Background:
- Breast cancer is a leading cause of cancer death in women globally.
- Understanding modifiable risk factors like physical activity is crucial for prevention.
Purpose of the Study:
- To synthesize epidemiologic evidence on the association between physical activity and breast cancer risk.
- To identify specific types and durations of physical activity with the greatest impact on risk reduction.
Main Methods:
- Systematic review and meta-analysis of 73 global studies on physical activity and breast cancer.
- Analysis of associations based on activity type, intensity, duration, menopausal status, and other factors.
Main Results:
- Physically active women experienced a 25% average reduction in breast cancer risk compared to inactive women.
- Strongest risk reductions were observed for lifelong, postmenopausal, moderate-to-vigorous intensity, and regular recreational physical activity.
- Evidence suggests a more pronounced effect in normal-weight, nulliparous postmenopausal women without a family history.
Conclusions:
- Physical activity is a significant protective factor against breast cancer, likely through multiple biological pathways including adiposity, hormones, and inflammation.
- Further research, including biomarker studies and randomized controlled trials, is needed to clarify optimal exercise prescriptions for risk reduction.
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