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Updated: Jun 6, 2026

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
Published on: February 13, 2016
Bioresponsive matrices in drug delivery
Jin-Oh You1, Dariela Almeda, George Jc Ye
1School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA. auguste@seas.harvard.edu.
Smart drug delivery systems utilize "intelligent" biomaterials that respond to environmental cues for controlled therapeutic release. This review highlights recent advances in stimuli-responsive polymers for targeted drug delivery, minimizing side effects.
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Polymer Chemistry
Background:
- Traditional drug delivery focuses on controlled release and cell targeting using degradable polymers and labeled vehicles.
- Recent advancements explore
- smart
- or "intelligent" biomaterials that respond to environmental cues for drug release and localization.
Purpose of the Study:
- To review recent progress in stimuli-responsive drug delivery systems.
- To highlight the potential of "smart" biomaterials in eliciting effective therapeutic doses with minimal adverse effects.
Main Methods:
- Review of scientific literature on stimuli-responsive polymers for drug delivery.
- Focus on materials responding to pH, light, temperature, ultrasound, magnetism, and biomolecules.
Main Results:
- Development of novel biomaterials that trigger drug release based on specific environmental stimuli.
- Investigation of polymers responding to single or multiple stimuli for enhanced drug delivery.
Conclusions:
- Stimuli-responsive drug delivery systems offer a promising approach for targeted and controlled therapeutic administration.
- The use of "smart" biomaterials has the potential to revolutionize drug delivery by improving efficacy and reducing side effects.
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