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Updated: Jun 6, 2026

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
Spectral domain optical coherence tomography in the diagnosis and management of glaucoma
Ahmad A Aref1, Donald L Budenz
1Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 900 NW 17th Street, Miami, FL 33136, USA.
Abstract:
Spectral domain optical coherence tomography (SD-OCT) is a relatively new imaging technology that is being used for the diagnosis and management of glaucoma. This article presents a review of the specific parameters analyzed by SD-OCT and the diagnostic capability, reproducibility, and limitations of the device. SD-OCT parameters useful for diagnosis of glaucoma include retinal nerve fiber layer analysis, optic nerve head analysis, and ganglion cell complex analysis. These parameters have proven to be at least as equivalent to time-domain technology in terms of diagnostic capability and superior in terms of reproducibility. SD-OCT technology may be limited by signal quality, image artifact, and confounding ocular disease.
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