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Updated: Jun 6, 2026
09:29
Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4
Published on: August 21, 2017
[Recurrent inflammatory optic neuritis and neuromyelitis optica].
1Service de neurologie, CHU de Strasbourg, 1, place de l'hôpital, 67091 Strasbourg cedex, France. jerome.de.seze@chru-strasbourg.fr
Revue Neurologique
|December 4, 2010
Summary
Idiopathic optic neuritis (ON) can recur as relapsing ON (RION) or progress to neuromyelitis optica (NMO). Anti-NMO IgG antibodies may predict NMO development, aiding diagnosis and prognosis.
Area of Science:
- Neurology
- Ophthalmology
- Immunology
Context:
- Inflammatory optic neuritis (ON) is a common neurological and ophthalmological presentation.
- Idiopathic ON, with normal MRI and CSF, often has a suspected viral cause.
- Recurrence (RION) or myelitis (NMO) can occur, necessitating further investigation.
Purpose:
- To differentiate between relapsing inflammatory optic neuritis (RION) and neuromyelitis optica (NMO).
- To summarize diagnostic and prognostic criteria for these conditions.
- To highlight the potential predictive value of anti-NMO IgG antibodies.
Summary:
- ON can evolve into RION or NMO, particularly when initial diagnostics are normal.
- Predictive criteria for recurrence or spinal cord involvement are largely unknown.
- Anti-NMO IgG antibodies show high specificity for predicting future NMO development.
Impact:
- Aids in distinguishing between RION and NMO.
- Provides insights into prognostic markers for ON.
- Facilitates earlier diagnosis and management of inflammatory optic neuropathies.
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