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Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
Published on: October 10, 2016
Block Ionomer Complex Micelles with Cross-Linked Cores for Drug Delivery.
Jong Oh Kim1, Nataliya V Nukolova, Hardeep S Oberoi
1Department of Pharmaceutical Sciences and Center for Drug Delivery and Nanomedicine, College of Pharmacy, University of Nebraska Medical Center, 985830 Nebraska Medical Center, Omaha, NE 68198-5830, USA.
Polymer Science. Series A, Chemistry, Physics
|December 4, 2010
Summary
Researchers developed pH-responsive nanogels from block ionomer complex micelles. These cross-linked micelles show potential for controlled drug delivery, specifically for cisplatin.
Area of Science:
- Polymer Chemistry
- Materials Science
- Nanotechnology
Background:
- Soft polymeric nanomaterials offer unique properties for various applications.
- Block ionomer complex micelles provide a versatile platform for nanostructure fabrication.
- pH-responsive materials are crucial for targeted drug delivery systems.
Purpose of the Study:
- To synthesize and characterize soft polymeric nanomaterials using a template-assisted method.
- To investigate the pH-dependent swelling behavior of the synthesized nanogels.
- To evaluate the potential of these nanogels for drug delivery applications.
Main Methods:
- Template-assisted synthesis of core-shell block ionomer complex micelles.
- Condensation of poly(ethylene oxide)-b-polycarboxylate anions with metal ions.
- Chemical cross-linking of polyion chains within micelle cores.
- Evaluation of cisplatin loading and release kinetics.
Main Results:
- Successfully synthesized pH-dependent swelling nanogels from cross-linked block ionomer micelles.
- Identified key structural determinants (block ionomer, metal ions, cross-links, cross-linking degree) influencing self-assembly and swelling.
- Demonstrated the capability of these nanogels for loading and releasing cisplatin.
Conclusions:
- Cross-linked block ionomer micelles form promising pH-responsive nanogels.
- The developed nanogels exhibit tunable swelling behavior based on structural parameters.
- These materials hold significant potential for effective pharmaceutical agent delivery.
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