Paper-based SERS swab for rapid trace detection on real-world surfaces

Area of Science:

• Analytical Chemistry
• Materials Science
• Nanotechnology

Background:

• Surface-enhanced Raman scattering (SERS) is a powerful technique for trace detection.
• Conventional rigid SERS substrates exhibit poor sample collection efficiency due to limited conformal contact.
• Efficient analyte collection is crucial for effective trace detection using SERS.

Discussion:

• A novel SERS substrate utilizing gold nanorods adsorbed onto common filter paper was developed.
• The filter paper's fibrous structure facilitates conformal contact and efficient analyte uptake.
• This design significantly enhances sample collection compared to traditional rigid substrates.

Key Insights:

• Demonstrated detection of trace analytes (140 pg over 4 cm2) via simple surface swabbing.
• The hierarchical structure of paper acts as a 3D vasculature for analyte transport to hot spots.
• Achieved dramatically enhanced sample collection efficiency through conformal contact.

Outlook:

• The developed SERS substrate offers a simple, efficient, and cost-effective solution for trace detection.
• This innovation moves SERS-based trace analysis closer to practical, real-world applications.
• Further research can explore diverse applications in environmental monitoring and security screening.