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A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
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Published on: January 11, 2020

Association between licence status and medication errors.

Sharon Conroy1

  • 1Academic Division of Child Health, University of Nottingham, The Medical School, Derbyshire Children's Hospital, Derby, UK. sharon.conroy@nottingham.ac.uk

Archives of Disease in Childhood
|December 7, 2010
PubMed
Summary

Unlicensed and off-label drug use in children is linked to medication errors. These errors, particularly those causing moderate harm, were more frequent with non-licensed or off-label medications.

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Area of Science:

  • Pediatric Pharmacology
  • Medication Safety
  • Drug Utilization

Background:

  • Unlicensed and off-label medication use in pediatric populations is prevalent.
  • This practice is associated with recognized challenges in child healthcare.

Purpose of the Study:

  • To investigate the association between medication errors and the licensing status of drugs used in children.
  • To determine if unlicensed or off-label drug use increases the risk of medication errors.

Main Methods:

  • Analysis of medication error reports from a UK children's hospital (2004-2006).
  • Categorization of errors by drug license status (licensed, unlicensed, off-label) and degree of harm.
  • Comparison with the incidence of unlicensed and off-label drug use.

Main Results:

  • 13% of medication errors (20/158) caused moderate harm, with 12 of these involving unlicensed/off-label drugs.
  • Unlicensed drug use showed a significantly higher association with errors in both children and neonates compared to licensed use.
  • No medication errors resulted in severe harm.

Conclusions:

  • Findings suggest a significant association between unlicensed drug use and medication errors in neonates and children.
  • Medication errors leading to moderate harm were more likely to involve unlicensed or off-label drugs than licensed ones.