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Updated: Jun 6, 2026

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
Published on: February 6, 2015
Evolutionary dynamics of cancer prevention
Robert A Gatenby1, Robert J Gillies, Joel S Brown
1Departments of Radiology and Integrated Mathematical Oncology, Moffitt Cancer Center, USA. Robert.Gatenby@Moffitt.org
Abstract:
Multicellular organisms must evolve mechanisms to suppress cancer formation prior to reproduction, and we propose that the organizational structure of normal epithelium is one such strategy. Understanding evolved host cancer suppression mechanisms is essential to defining the first steps of carcinogenesis and developing rational cancer prevention strategies.
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