Related Experiment Video
Updated: Jul 25, 2026
Use of a Hanging-weight System for Liver Ischemia in Mice
Published on: August 7, 2012
[The protective effect of XD in ConA-induced liver injury]
Xiao-Bin Liu1, Jing Wang, Qian-Qian Zhang
1The Medical College of Yanan University; Yan'an 716000, China. lxb2411817@163.com
Aim:
To explore the protective effect and its mechanism of Modified Xiaochaihu decoction(MXD) in the liver injury of mice. METHORDS: Using Reitman methord to examine serum ALT and ATS; Using sandwich enzyme immunoassay ABC-ELISA to examine serum TNF-α and IFN-γ.
Results:
Serum ALT and ATS of MXD large dose group and Xiaochaihu decoction (XD )group were lower than that of animal models group, there was significant difference among groups (P<0.05). There were not significant difference (P>0.05) between serum ALT and ATS of MXD small dose group and that of animal models group; MXD large dose group, XD group and Biphenyldimethylesterate (DDB) group are similar, no difference (P>0.05). Serum TNF-α and IFN-γ of MXD large dose group and XD group were significant lower than that of animal models group, there was significant difference among groups (P<0.05). Serum TNF-α and IFN-γ of XD group ware higher than that of MXD large dose group, there was significant difference among groups (P<0.05). MXD large dose group, XD group and DDB group were similar, no difference.
Conclusions:
Xiaocaihu decoction possesses the effect of pro2 tection of hepatic impairment and the protective mechanism might be associated with the inhibition of apoptosis and immunomodulation.
