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Updated: Jun 6, 2026

Multi-step Variable Height Photolithography for Valved Multilayer Microfluidic Devices
Published on: January 27, 2017
Two-step photolithography to fabricate multilevel microchannels.
1Department of Bio and Brain Engineering, College of Life Science and Bioengineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon 305-701, South Korea.
Two-step photolithography precisely controls photoresist thickness for microchannels. This method enables the creation of multilevel features and microfluidic devices like cross-flow filters.
Area of Science:
- Materials Science
- Microfluidics
- Lithography
Background:
- Controlling feature thickness in microchannels is crucial for microfluidic device performance.
- Traditional photolithography methods face challenges in achieving precise thickness control for complex structures.
Purpose of the Study:
- To investigate the variation of photoresist thickness in patterned microchannels using a two-step photolithography technique.
- To understand the factors influencing photoresist thickness during the two-step process.
- To demonstrate the application of this method in fabricating microfluidic devices.
Main Methods:
- Utilized a two-step photolithography process to pattern microchannel features in photoresist.
- Analyzed the influence of first-step pattern dimensions (thickness and width) and second-step spin-coated film thickness on the final photoresist thickness.
- Investigated the role of capillary pressure in determining photoresist film thickness within critical pattern widths.
Main Results:
- The final photoresist thickness is a function of both the initial photoresist pattern and the subsequent spin-coated layer.
- Thickness variation is significant within critical pattern widths where capillary pressure dominates.
- Successfully fabricated multilevel channel features using the developed two-step photolithography method.
Conclusions:
- Two-step photolithography offers a viable method for precise control over photoresist thickness in microchannel fabrication.
- This technique facilitates the creation of complex microfluidic architectures, including multilevel channels.
- Demonstrated the utility of this approach by fabricating a functional cross-flow filter with dual pore sizes.
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