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Published on: August 30, 2024
[Arrhythmia triggered by stretching rabbit left ventricles and the block effect of streptomysin]
Hua Wei1, Zhi-Fei Zhang, Hai-Xia Huang
1Department of Physiology, Capital Medical University, Beijing 100069, China.
Aim:
To observe the effect of stretching left ventricles in the end of action potential on rabbit cardiac activity, and to investigate its possible mechanisms.
Methods:
Stretch (120 mmHg, 50 ms) was applied in the end of action potential by the pressure-clamp technique to observe if there would be any changes in rabbit cardiac activity and streptomycin (500 micromol/L) was used to identify the mechanism.
Results:
Stretch in the end of action potential caused arrhythmia (P < 0.05) and streptomycin blocked the above effect (P < 0.05).
Conclusion:
Streptomycin could block the effect of stretching left ventricles in the end of action potential on rabbit cardiac activity, which indicates that stretch-activated ion channels involve it.
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