Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Depression: Overview01:18

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Classification of Illness01:17

Classification of Illness

The meaning of illness is individualized to each person who experiences an alteration in health. In contrast, disease is a medical term indicating a pathological change in the structure and function of the body or mind. It is a condition that has specific symptoms and boundaries.
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe and...
Factors Affecting Illness01:18

Factors Affecting Illness

When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness, disability,...
Long-term Depression01:05

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Therapeutic use of Gastrografin in the management of adhesional and non-adhesional bowel obstruction.

Annals of the Royal College of Surgeons of England·2026
Same author

The evolution of training in robotic colorectal surgery.

Journal of robotic surgery·2025
Same author

Repair of oesophageal atresia by consultants and supervised trainees results in similar outcomes.

Annals of the Royal College of Surgeons of England·2020
Same author

Higher risk breast screening: cancer detection rates, recall rates, and attendance rates in Northern Ireland.

Clinical radiology·2019
Same author

A method for performing intraoperative enteroscopy.

Annals of the Royal College of Surgeons of England·2016
Same author

Radon testing in rapid access lung clinics: an opportunity for secondary prevention.

Irish journal of medical science·2016
Same journal

Dr Archibald Hewan (1832-1883) and the University of Glasgow's medical libraries.

The journal of the Royal College of Physicians of Edinburgh·2025
Same journal

Joyce Grainger Learning Centre.

The journal of the Royal College of Physicians of Edinburgh·2025
Same journal

Features in this issue.

The journal of the Royal College of Physicians of Edinburgh·2025
Same journal

An unusual case of cutaneous tuberculosis and paradoxical TB in a patient with spondyloarthritis treated with adalimumab.

The journal of the Royal College of Physicians of Edinburgh·2025
Same journal

Leptospiral infection overlapping with autoimmune hepatitis: A diagnostic conundrum.

The journal of the Royal College of Physicians of Edinburgh·2025
Same journal

Tocilizumab vs bevacizumab in critically ill COVID-19 patients: Registry-based prospective study.

The journal of the Royal College of Physicians of Edinburgh·2025
See all related articles

Related Experiment Video

Updated: Jun 6, 2026

A New Method for Inducing a Depression-Like Behavior in Rats
07:57

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

Depression in physical illness.

R Smyth1

  • 1Department of Psychological Medicine, Royal Infirmary of Edinburgh, Edinburgh EH16 4SA, UK. roger.smyth@luht.scot.nhs.uk.

The Journal of the Royal College of Physicians of Edinburgh
|December 15, 2010
PubMed
Summary
This summary is machine-generated.

Depression is common, especially with physical illness, leading to under-diagnosis and worse outcomes. Effective treatments improve quality of life and physical health.

More Related Videos

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
06:55

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

Related Experiment Videos

Last Updated: Jun 6, 2026

A New Method for Inducing a Depression-Like Behavior in Rats
07:57

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
06:55

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

Area of Science:

  • Psychiatry
  • Internal Medicine
  • General Practice

Background:

  • Depressive illnesses frequently co-occur with physical health conditions.
  • Depression in medical patients often goes unrecognized, leading to under-treatment.
  • Comorbid depression is linked to increased illness severity, functional decline, higher healthcare expenses, and mortality.

Purpose of the Study:

  • To highlight the importance of recognizing and managing depression in patients with physical illnesses.
  • To inform medical practitioners about the symptoms, diagnosis, and treatment of depressive illnesses.

Main Methods:

  • Literature review on the prevalence and impact of depression in medical settings.
  • Analysis of the consequences of untreated depression in patients with co-morbid physical disorders.

Main Results:

  • Untreated depression exacerbates physical illness, increasing morbidity and mortality.
  • Effective treatment of depression improves patient quality of life and overall health outcomes.
  • Awareness among medical doctors is crucial for timely diagnosis and intervention.

Conclusions:

  • Medical professionals must be vigilant for depressive symptoms in all patients.
  • Integrated care approaches are necessary to address co-morbid depression effectively.
  • Prompt diagnosis and treatment of depression are vital for improving patient prognosis and reducing healthcare burden.