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[Heat injury induced apoptosis in rat striatum neurons]
Wen-Hong Fan1, Min Li, Lu-Ming Wang
1Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing 100850, China.
Aim:
To investigate the effect of hyperthermia on apoptosis of cultivated striatum neurons in the rat.
Methods:
After 30 min hyperthermia in 43 degrees, the Ca2+ concentration, the mitochondria membrane potential of the neuron were detected by Laser Scanning Confocal Microscopy (LSCM). The apoptosis of striatum neurons was detected by TUNEL staining.
Results:
Heat stress at 43 degrees C for 40 min caused an increase in the Ca2+ concentration of striatum neurons and a decrease in the mitochondria membrane potential of the striatum neurons.
Conclusion:
The striatum shows more apoptosis neurons after heat stress.
