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Updated: Jun 6, 2026

Analysis of Cell Migration within a Three-dimensional Collagen Matrix
08:02

Analysis of Cell Migration within a Three-dimensional Collagen Matrix

Published on: October 5, 2014

CXCL12-CXCR4 axis in angiogenesis, metastasis and stem cell mobilization

S Liekens1, D Schols, S Hatse

  • 1Rega Institute for Medical Research, Department of Microbiology and Immunology, K.U. Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium. sandra.liekens@rega.kuleuven.be

Current Pharmaceutical Design
|December 17, 2010
PubMed
Summary

Stromal cell-derived factor-1 (SDF-1)/CXCL12 and its receptor CXCR4 are crucial in immune cell trafficking, tumor metastasis, and HIV entry. CXCR4 antagonists show promise for treating cancer, HIV, and mobilizing hematopoietic stem cells.

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