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Updated: Jun 6, 2026

Hybrid Ensemble and Single-molecule Assay to Image the Motion of Fully Reconstituted CMG
Published on: July 26, 2024
Sister acts: coordinating DNA replication and cohesion establishment
Rebecca Sherwood1, Tatsuro S Takahashi, Prasad V Jallepalli
1Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.
Abstract:
The ring-shaped cohesin complex links sister chromatids and plays crucial roles in homologous recombination and mitotic chromosome segregation. In cycling cells, cohesin's ability to generate cohesive linkages is restricted to S phase and depends on loading and establishment factors that are intimately connected to DNA replication. Here we review how cohesin is regulated by the replication machinery, as well as recent evidence that cohesin itself influences how chromosomes are replicated.
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