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A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound
Published on: March 21, 2025
Single focus prostate cancer: pathological features and ERG fusion status
Sara M Falzarano1, Ming Zhou, Adrian V Hernandez
1Division of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA.
The Journal of Urology
|December 21, 2010
Summary
Single focus prostate cancer, found in 9.6% of radical prostatectomies, often presents unilaterally in the peripheral zone. Despite a tendency for higher grade, most cases remain organ-confined, suggesting a single clone origin.
Area of Science:
- Urology
- Oncology
- Pathology
Background:
- Single focus prostate cancer is a distinct pathological entity.
- Understanding its characteristics is crucial for accurate staging and treatment planning.
Purpose of the Study:
- To evaluate the clinicopathological features of single focus prostate cancer.
- To assess its clinical relevance and the incidence of TMPRSS2-ERG rearrangement.
Main Methods:
- Review of 1,100 radical prostatectomy records.
- Determination of tumor outline and foci number.
- Assessment of pathological characteristics and ERG fusion status in single focus cases.
Main Results:
- Single focus prostate cancer identified in 106 cases (9.6%).
- Predominantly unilateral (81%) and peripheral zone origin (98%).
- Organ-confined disease (pT2) in 62%, with 68% showing ERG fusion.
Conclusions:
- Single focus prostate cancer typically involves one lobe and originates from the peripheral zone.
- Despite potential for high-grade disease, most cases are organ-confined.
- Low incidence of intratumor heterogeneity in fusion-positive cases suggests monoclonal origin.
