[Anti-tumoral matrikines: potential interest in oncology]

The word 'matrikine' designates certain peptides derived from partial degradation of extracellular matrix macromolecules and capable of modulating cellular activities. Some matrikines have been shown to inhibit tumor progression and/or neo-angiogenesis, suggesting they may have therapeutic potential. This review examines the main matrikines with anti-tumoral properties, and particularly those originating from basement membrane macromolecules. After a brief description of their discovery and main characteristics, we discuss their mode of production, mechanism of anti-tumor action, and therapeutic potential.