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Updated: Jun 5, 2026
Efficient Synthesis of Polyfunctionalized Benzenes in Water via Persulfate-promoted Benzannulation of α,β-Unsaturated Compounds and Alkynes
Published on: December 16, 2019
An efficient copper-catalyzed carbon-sulfur bond formation protocol in water
Fang Ke1, Yanyang Qu, Zhaoqiong Jiang
1Institute of Homogeneous Catalysis, College of Chemistry, Sichuan University, Chengdu 610041, China.
This study presents an efficient copper-catalyzed method for creating carbon-sulfur bonds, synthesizing various diaryl sulfides from aryl halides and potassium thiocyanate with high yields up to 94%.
Area of Science:
- Organic Chemistry
- Catalysis
- Synthetic Chemistry
Background:
- Carbon-sulfur (C-S) bond formation is crucial in synthesizing organosulfur compounds.
- Developing efficient catalytic methods for C-S coupling remains an active area of research.
Purpose of the Study:
- To report an efficient copper-catalyzed protocol for C-S bond formation.
- To synthesize diaryl sulfides from aryl halides and potassium thiocyanate.
Main Methods:
- Copper-catalyzed coupling reaction.
- Utilized aryl halides and potassium thiocyanate as starting materials.
- Optimization of reaction conditions for efficient C-S bond formation.
Main Results:
- Successfully synthesized a variety of diaryl sulfides.
- Achieved good to excellent yields, with some reactions reaching up to 94%.
- Demonstrated the efficiency and broad applicability of the developed protocol.
Conclusions:
- The reported copper-catalyzed method provides an efficient route to diaryl sulfides.
- The protocol offers a valuable tool for the synthesis of diverse organosulfur compounds.
- High yields and substrate scope highlight the practical utility of this synthetic approach.
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