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Updated: Jun 5, 2026
Quantitative and Temporal Control of Oxygen Microenvironment at the Single Islet Level
Published on: November 17, 2013
[Relationship between enhanced anoxic tolerance induced by hypoxic preconditioning and Na+, K+ currents in cultured
Li-Ying Wu1, Wei Liu, Ai-Shi Ding
1Department of Neurobiology, Institute of basic Medical Sciences, Academy of Military Medical Sciences, China.
Aim:
To investigate the relationship between enhanced anoxic tolerance induced by hypoxic preconditioning and Na+, K+ currents.
Methods:
After hypoxic preconditioning and acute anoxia the I(Na), I(K) were measured in cultured hypothalamic cells by patch-clamp whole cell recording technique.
Results:
The amplification of Na+ currents did not been significantly changed, but the amplification of K+ currents was in hypoxic preconditioning neurons; acute anoxia lead to the inhibition of Na+, K+ currents in the two groups, while Na+, K+ currents in non-preconditioned control group were inhibited severity than hypoxic preconditioning group.
Conclusion:
It is presumed enhanced anoxia tolerance induced by hypoxic preconditioning may be related to the opening of K+ channels.
